The Role of the Hedgehog Pathway Inhibitors in Hair Loss

So-called ‘hedgehog pathway inhibitors’ (HPI) such as vismodegib and sonidegib are effective therapies for treating basal cell carcinoma (BCC). HPI target overactive signals in the hedgehog molecular pathway that lead to the proliferation of cancer cells. However, when inhibiting the cancer cells, HPI also inhibit hair follicle (HF) growth which leads to hair loss in …